Meningococcal carriage and disease-Population biology and evolution

被引:254
作者
Caugant, Dominique A. [2 ,3 ]
Maiden, Martin C. J. [1 ]
机构
[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England
[2] Norwegian Inst Publ Hlth, WHO Collaborating Ctr Reference & Res Meningococc, Oslo, Norway
[3] Univ Oslo, Fac Dent, Inst Oral Biol, Oslo, Norway
基金
英国惠康基金;
关键词
Meningococcal disease; Carriage; Population structure; MENINGITIDIS SEROGROUP-B; COMPLETE GENOME SEQUENCE; DNA UPTAKE SEQUENCES; NEISSERIA-MENINGITIDIS; MOLECULAR EPIDEMIOLOGY; GENETIC DIVERSITY; CLONAL LINEAGES; STRAIN; RECOMBINATION; CAPSULE;
D O I
10.1016/j.vaccine.2009.04.061
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Meningococcal disease occurs worldwide with incidence rates varying from I to 1000 cases per 100,000. The causative organism, Neisseria meningitidis, is an obligate commensal of humans, which normally colonizes the mucosa of the upper respiratory tract without causing invasive disease, a phenomenon known as carriage. Studies using molecular methods have demonstrated the extensive genetic diversity of meningocococci isolated from carriers, in contrast to a limited number of genetic types, known as the hyperinvasive lineages, associated with invasive disease. Population and evolutionary models that invoke positive selection can be used to resolve the apparent paradox of virulent lineages persisting during the global spread of a non-clonal and normally commensal bacterium. The application of insights gained from studies of meningococcal population biology and evolution is important in understanding the spread of disease, as well as in vaccine development and implementation, especially with regard to the challenge of producing comprehensive vaccines based on sub-capsular antigens and measuring their effectiveness. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:B64 / B70
页数:7
相关论文
共 106 条
[1]  
Bart A, 2000, FEMS MICROBIOL LETT, V188, P111, DOI 10.1111/j.1574-6968.2000.tb09179.x
[2]   Species status of Neisseria gonorrhoeae:: evolutionary and epidemiological inferences from multilocus sequence typing [J].
Bennett, Julia S. ;
Jolley, Keith A. ;
Sparling, P. Frederick ;
Saunders, Nigel J. ;
Hart, C. Anthony ;
Feavers, Ian M. ;
Maiden, Martin C. J. .
BMC BIOLOGY, 2007, 5 (1)
[3]   Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18 [J].
Bentley, Stephen D. ;
Vernikos, George S. ;
Snyder, Lori A. S. ;
Churcher, Carol ;
Arrowsmith, Claire ;
Chillingworth, Tracey ;
Cronin, Ann ;
Davis, Paul H. ;
Holroyd, Nancy E. ;
Jagels, Kay ;
Maddison, Mark ;
Moule, Sharon ;
Rabbinowitsch, Ester ;
Sharp, Sarah ;
Unwin, Louise ;
Whitehead, Sally ;
Quail, Michael A. ;
Achtman, Mark ;
Barrell, Bart ;
Saunders, Nigel J. ;
Parkhill, Julian .
PLOS GENETICS, 2007, 3 (02) :230-240
[4]   A chromosomally integrated bacteriophage in invasive meningococci [J].
Bille, E ;
Zahar, JR ;
Perrin, A ;
Morelle, S ;
Kriz, P ;
Jolley, KA ;
Maiden, MCJ ;
Dervin, C ;
Nassif, X ;
Tinsley, CR .
JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (12) :1905-1913
[5]   Association of a Bacteriophage with Meningococcal Disease in Young Adults [J].
Bille, Emmanuelle ;
Ure, Roisin ;
Gray, Stephen J. ;
Kaczmarski, Edward B. ;
McCarthy, Noel D. ;
Nassif, Xavier ;
Maiden, Martin C. J. ;
Tinsley, Colin R. .
PLOS ONE, 2008, 3 (12)
[6]   EFFECT OF OUTER-MEMBRANE VESICLE VACCINE AGAINST GROUP-B MENINGOCOCCAL DISEASE IN NORWAY [J].
BJUNE, G ;
HOIBY, EA ;
GRONNESBY, JK ;
ARNESEN, O ;
HOLSTFREDRIKSEN, J ;
HALSTENSEN, A ;
HOLTEN, E ;
LINDBAK, AK ;
NOKLEBY, H ;
ROSENQVIST, E ;
SOLBERG, LK ;
CLOSS, O ;
ENG, J ;
FROHOLM, LO ;
LYSTAD, A ;
BAKKETEIG, LS ;
HAREIDE, B .
LANCET, 1991, 338 (8775) :1093-1096
[7]   SECRETOR STATUS, SMOKING AND CARRIAGE OF NEISSERIA-MENINGITIDIS [J].
BLACKWELL, CC ;
WEIR, DM ;
JAMES, VS ;
TODD, WTA ;
BANATVALA, N ;
CHAUDHURI, AKR ;
GRAY, HG ;
THOMSON, EJ ;
FALLON, RJ .
EPIDEMIOLOGY AND INFECTION, 1990, 104 (02) :203-209
[8]   Meningococcal meningitis:: Unprecedented incidence of serogroup X-related cases in 2006 in Niger [J].
Boisier, Pascal ;
Nicolas, Pierre ;
Djibo, Saacou ;
Taha, Muhamed-Kheir ;
Jeanne, Isabelle ;
Mainassara, Halima Boubacar ;
Tenebray, Bernard ;
Kairo, Kiari Kaka ;
Giorgini, Dario ;
Chanteau, Suzanne .
CLINICAL INFECTIOUS DISEASES, 2007, 44 (05) :657-663
[9]  
Brandtzaeg P., 2006, HDB MENINGOCOCCAL DI, P427, DOI [DOI 10.1002/3527608508.CH21, 10.1002/3527608508.CH21]
[10]   Multilocus sequence typing for global surveillance of meningococcal disease [J].
Brehony, Carina ;
Jolley, Keith A. ;
Maiden, Martin C. J. .
FEMS MICROBIOLOGY REVIEWS, 2007, 31 (01) :15-26