Decreases in CD5(+) B lymphocytes in children with the DiGeorge anomaly

被引:8
作者
Kourtis, AP
Ibegbu, CC
Lee, FK
Vogler, L
Philips, K
Nahmias, AJ
机构
[1] EMORY UNIV,DIV PEDIAT INFECT DIS EPIDEMIOL & IMMUNOL,ATLANTA,GA 30303
[2] EMORY UNIV,DIV ALLERGY & IMMUNOL,DEPT PEDIAT,ATLANTA,GA 30303
关键词
D O I
10.1046/j.1365-3083.1997.d01-127.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The authors evaluated the lymphocyte subsets in eight children with the DiGeorge anomaly, compared with 48 age-matched control infants. Of particular interest was the finding that the percentage and number of CD5(+) B lymphocytes were decreased in seven of the eight cases. This observation may provide insight into thymic function and the interaction of the B and T cell systems in some forms of congenital and acquired immunodeficiencies.
引用
收藏
页码:281 / 283
页数:3
相关论文
共 18 条
[1]   PREDICTION OF PERSISTENT IMMUNODEFICIENCY IN THE DIGEORGE ANOMALY [J].
BASTIAN, J ;
LAW, S ;
VOGLER, L ;
LAWTON, A ;
HERROD, H ;
ANDERSON, S ;
HOROWITZ, S ;
HONG, R .
JOURNAL OF PEDIATRICS, 1989, 115 (03) :391-396
[2]  
DRISCOLL DA, 1992, AM J HUM GENET, V50, P924
[3]   IMPAIRED LYMPHOCYTE-T8-MEDIATED SUPPRESSIVE ACTIVITY IN PATIENTS WITH PARTIAL DI GEORGE SYNDROME [J].
DURANDY, A ;
LEDEIST, F ;
FISCHER, A ;
GRISCELLI, C .
JOURNAL OF CLINICAL IMMUNOLOGY, 1986, 6 (03) :265-270
[4]   CATCH-22 [J].
HALL, JG .
JOURNAL OF MEDICAL GENETICS, 1993, 30 (10) :801-802
[5]  
HERZENBERG LA, 1992, ANN NY ACAD SCI, V651, P1
[6]  
HONG R, 1991, Immunodeficiency Reviews, V3, P1
[7]   SUBPOPULATIONS OF T-CELLS AND B-CELLS IN PERINATALLY HIV-INFECTED AND NONINFECTED AGE-MATCHED CHILDREN COMPARED WITH THOSE IN ADULTS [J].
IBEGBU, C ;
SPIRA, TJ ;
NESHEIM, S ;
MENDEZ, H ;
LEE, F ;
POLLIOTTI, B ;
CABA, J ;
NAHMIAS, A .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1994, 71 (01) :27-32
[8]  
IBEGBU CC, 1992, ANN NY ACAD SCI, V651, P572
[9]   FUNCTIONAL ANALYSES OF THYMIC CD5+ B-CELLS - RESPONSIVENESS TO MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II-RESTRICTED T-BLASTS BUT NOT TO LIPOPOLYSACCHARIDE OR ANTI-IGM PLUS INTERLEUKIN-4 [J].
INABA, M ;
INABA, K ;
ADACHI, Y ;
NANGO, K ;
OGATA, H ;
MURAMATSU, S ;
IKEHARA, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (01) :321-326
[10]  
ISAACSON PG, 1987, LANCET, V2, P1488