Sonogashira cross-couplings of ynamides. Syntheses of urethane- and sulfonamide-terminated conjugated phenylacetylenic systems

被引：62

作者：

Tracey, MR ^{[1
]}

Zhang, YS ^{[1
]}

Frederick, MO ^{[1
]}

Mulder, JA ^{[1
]}

Hsung, RP ^{[1
]}

机构：

[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 13期

关键词：

D O I：

10.1021/ol0493251

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first successful Sonogashira coupling of ynamides with aryl and vinyl iodides is described here. This study resolves the problem of the competing pathway involving homocoupling of ynamides and provides a practical entry to novel urethane- or sulfonamide-terminated conjugated acetylenic systems. An interesting tandem hydrohalogenation and Sonogashira coupling was also observed to give an en-ynamide.

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收藏

页码：2209 / 2212

页数：4

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