Formation of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway

被引：118

作者：

Kuzuyama, T

Takagi, M

Kaneda, K

Dairi, T

Seto, H ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan

[2] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 05期

基金：

日本学术振兴会;

关键词：

isopentenyl diphosphate; 2-C-methyl-D-erythritol; 4-phosphate; 4-(cytidine 5 '-diphospho)-2-C-methyl-D-erythritol; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;

D O I：

10.1016/S0040-4039(99)02143-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-C-Methyl- D-erythritol-4-phosphate is transformed to 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol in the presence of cytidine 5'-triphosphate by a novel Escherichia coli enzyme, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, involved in the nonmevalonate pathway. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：703 / 706

页数：4

共 5 条

[1] Fosmidomycin, a specific inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis [J].