Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection

被引：53

作者：

Allen, TM

Jing, PC

Calore, B

Horton, H

O'Connor, DH

Hanke, T

Piekarczyk, M

Ruddersdorf, R

Mothé, BR

Emerson, C

Wilson, N

Lifson, JD

Belyakov, IM

Berzofsky, JA

Wang, CX

Allison, DB

Montefiori, DC

Desrosiers, RC

Wolinsky, S

Kunstman, KJ

Altman, JD

Sette, A

McMichael, AJ

Watkins, DI

机构：

[1] Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI 53715 USA

[2] John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DS, England

[3] NCI, Retroviral Pathogenesis Lab, AIDS Vaccine Program, SAIC Frederick,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA

[4] NCI, NIH, Bethesda, MD 20892 USA

[5] Univ Alabama Birmingham, Sect Stat Genet, Dept Biostat, Birmingham, AL 35294 USA

[6] Univ Alabama Birmingham, Clin Nutr Res Ctr, Birmingham, AL 35294 USA

[7] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

[8] New England Reg Primate Res Ctr, Southborough, MA 01772 USA

[9] Northwestern Univ, Sch Med, Chicago, IL 60611 USA

[10] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[11] Epimmune Inc, San Diego, CA 92121 USA

[12] Univ Wisconsin, Sch Med, Dept Pathol & Lab Med, Madison, WI 53706 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 20期

关键词：

D O I：

10.1128/JVI.76.20.10507-10511.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.

引用

页码：10507 / 10511

页数：5

共 41 条

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