Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS

被引：126

作者：

Zheng, CY

Nennesmo, I

Fadeel, B

Henter, JI ^{[1
]}

机构：

[1] Karolinska Hosp, Childhood Canc Res Unit, Dept Woman & Child Hlth, S-17176 Stockholm, Sweden

[2] Huddinge Univ Hosp, Dept Lab Med, Div Pathol, S-14186 Huddinge, Sweden

[3] Karolinska Inst, Inst Environm Med, Div Mol Toxicol, S-10401 Stockholm, Sweden

来源：

ANNALS OF NEUROLOGY | 2004年 / 56卷 / 04期

关键词：

D O I：

10.1002/ana.20223

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with the death of motor neurons in the spinal cord and brainstem. The cause of ALS is unknown and there is no cure. This study demonstrates, for the first time, that vascular endothelial growth factor (VEGF) delays progression of symptoms and prolongs survival in a Cu/Zn superoxide dismutase (SOD1) transgenic mouse model of ALS. These observations suggest that VEGF or related compounds, might be of value in the treatment of ALS patients.

引用

页码：564 / 567

页数：4

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