Synthesis and biological evaluation of γ-fluoro-β, γ-unsaturated acids

被引：20

作者：

Asakura, Noriaki

Usuki, Yoshinosuke ^{[1
]}

Iio, Hideo

Tanaka, Toshio

机构：

[1] Osaka City Univ, Grad Sch Sci, Dept Mat Sci, Sumiyoshi, Osaka 5588585, Japan

[2] Osaka City Univ, Grad Sch Sci, Dept Biol, Sumiyoshi, Osaka 5588585, Japan

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2006年 / 127卷 / 06期

关键词：

alpha-fluoro sulfone; Julia-Lythgoe olefination; monofluorinated building block; antifungal activity;

D O I：

10.1016/j.jfluchem.2006.02.016

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Several gamma-fluoro-beta, gamma-unsaturated acids, fluorine-containing analogues of N-acyl glycines, were synthesized via Julia-Lythgoe olefination. The antimicrobial activities of these compounds and synthetic intermediates were evaluated. Analogues with an octyl group showed in vitro antifungal activity agaist Penicillium chrysogenum IFO4626. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：800 / 808

页数：9

共 18 条

[1] A new synthesis of α-fluorovinylsulfones utilizing the Peterson olefination methodology [J].