An online database for brain disease research

被引：90

作者：

Higgs, Brandon W. ^{[1
]}

Elashoff, Michael

Richman, Sam

Barci, Beata

机构：

[1] Elashoff Consulting LLC, Germantown, MD 20876 USA

[2] Stanley Med Res Inst, Bethesda, MD 20814 USA

来源：

BMC GENOMICS | 2006年 / 7卷 / 1期

关键词：

D O I：

10.1186/1471-2164-7-70

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: The Stanley Medical Research Institute online genomics database (SMRIDB) is a comprehensive web-based system for understanding the genetic effects of human brain disease (i.e. bipolar, schizophrenia, and depression). This database contains fully annotated clinical metadata and gene expression patterns generated within 12 controlled studies across 6 different microarray platforms. Description: A thorough collection of gene expression summaries are provided, inclusive of patient demographics, disease subclasses, regulated biological pathways, and functional classifications. Conclusion: The combination of database content, structure, and query speed offers researchers an efficient tool for data mining of brain disease complete with information such as: cross-platform comparisons, biomarkers elucidation for target discovery, and lifestyle/demographic associations to brain diseases.

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页数：17

相关论文

共 11 条

[1] Bayesian hierarchical error model for analysis of gene expression data [J].

Cho, H ;

Lee, JK .

BIOINFORMATICS, 2004, 20 (13) :2016-2025

[2]

IACOBAS DA, 2003, ROM J PHYSL, V39, P2002

[3] Comparison of microarray-based mRNA profiling technologies for identification of psychiatric disease and drug signatures [J].

Jurata, LW ;

Bukhman, YV ;

Charles, V ;

Capriglione, F ;

Bullard, J ;

Lemire, AL ;

Mohammed, A ;

Pham, Q ;

Laeng, P ;

Brockman, JA ;

Altar, CA .

JOURNAL OF NEUROSCIENCE METHODS, 2004, 138 (1-2) :173-188

[4] Analysis of matched mRNA measurements from two different microarray technologies [J].

Kuo, WP ;

Jenssen, TK ;

Butte, AJ ;

Ohno-Machado, L ;

Kohane, IS .

BIOINFORMATICS, 2002, 18 (03) :405-412

[5] Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells [J].

Lee, JK ;

Bussey, KJ ;

Gwadry, FG ;

Reinhold, W ;

Riddick, G ;

Pelletier, SL ;

Nishizuka, S ;

Szakacs, G ;

Annereau, JP ;

Shankavaram, U ;

Lababidi, S ;

Smith, LH ;

Gottesman, MM ;

Weinstein, JN .

GENOME BIOLOGY, 2003, 4 (12)

[6] Differential gene expression patterns revealed by oligonucleotide versus long cDNA arrays [J].

Li, J ;

Pankratz, M ;

Johnson, JA .

TOXICOLOGICAL SCIENCES, 2002, 69 (02) :383-390

[7] A comparison of oligonucleotide and cDNA-based microarray systems [J].

Mah, N ;

Thelin, A ;

Lu, T ;

Nikolaus, S ;

Kühbacher, T ;

Gurbuz, Y ;

Eickhoff, H ;

Klöppel, G ;

Lehrach, H ;

Mellgård, B ;

Costello, CM ;

Schreiber, S .

PHYSIOLOGICAL GENOMICS, 2004, 16 (03) :361-370

[8]

MECHAM B, 2004, NUCLEIC ACIDS RES, V32, P9

[9] Reproducibility of gene expression across generations of Affymetrix microarrays [J].

Nimgaonkar, A ;

Sanoudou, D ;

Butte, AJ ;

Haslett, JN ;

Kunkel, LM ;

Beggs, AH ;

Kohane, IS .

BMC BIOINFORMATICS, 2003, 4 (1)

[10] Analysis of strain and regional variation in gene expression in mouse brain [J].

Pavlidis, Paul ;

Noble, William S. .

GENOME BIOLOGY, 2001, 2 (10)