Protein metabolism in rheumatoid arthritis and aging - Effects of muscle strength training and tumor necrosis factor alpha

被引:84
作者
Rall, LC
Rosen, CJ
Dolnikowski, G
Hartman, WJ
Lundgren, N
Abad, LW
Dinarello, CA
Roubenoff, R
机构
[1] TUFTS UNIV,JMUSDA,HNRCA,BOSTON,MA 02111
[2] ST JOSEPH HOSP,MAINE CTR OSTEOPOROSIS RES & EDUC,BANGOR,ME
[3] TUFTS UNIV,SCH MED,TUPPER RES INST,BOSTON,MA 02111
[4] TUFTS UNIV NEW ENGLAND MED CTR,BOSTON,MA 02111
来源
ARTHRITIS AND RHEUMATISM | 1996年 / 39卷 / 07期
关键词
D O I
10.1002/art.1780390707
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To determine the effects of rheumatoid arthritis (RA) on whole-body protein metabolism. Methods. We examined protein metabolism and its hormonal and cytokine mediators before and 12 weeks after progressive resistance muscle strength training in 8 healthy young (mean +/- SD age 25 +/- 2 years) and 8 healthy elderly (70 +/- 5 years) men and women, and in 8 adults with RA (42 +/- 13 years). An additional 6 healthy elderly subjects (69 +/- 3 years) served as a swimming-only control group. Results. Subjects with RA had higher rates of protein breakdown than did young or elderly healthy subjects (79.9 +/- 17.2 versus 60.3 +/- 5.8 and 63.7 +/- 12.4 mu moles/gm total body potassium/hour, respectively, P < 0.05), while there was no effect of age per se. Patients treated with methotrexate had normal rates of protein breakdown (P < 0.01 versus RA without methotrexate; P not significant versus healthy young subjects). Increased protein catabolism in RA was no longer evident after strength training, In multiple regression analysis, levels of tumor necrosis factor alpha (TNF alpha) (r = 0.47, P = 0.01) and growth hormone (r = -0.51, P = 0.006) were associated with protein breakdown, and plasma glucagon levels were inversely correlated with protein synthesis (r = -0.45, P = 0.02), Growth hormone (r = -0.56, P = 0.002) and glucagon (r = 0.45, P = 0.04, levels were associated with protein oxidation. Conclusion. Adults with RA have increased whole-body protein breakdown, which correlates with growth hormone, glucagon, and TNF alpha production.
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页码:1115 / 1124
页数:10
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