A computational tensegrity model predicts dynamic rheological behaviors in living cells

被引：90

作者：

Sultan, C

Stamenovic, D

Ingber, DE

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp, Vasc Biol Program,Dept Pathol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Childrens Hosp, Vasc Biol Program,Dept Surg, Boston, MA 02115 USA

[3] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 2004年 / 32卷 / 04期

关键词：

tensegrity; dynamics; cell frequency response;

D O I：

10.1023/B:ABME.0000019171.26711.37

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Rheological properties of living cells play a key role in the control of cell shape, growth, movement, and contractility, yet little is known about how these properties are governed. Past approaches to understanding cell mechanics focused on the contributions of membranes, the viscous cytoplasm, and the individual filamentous biopolymers that are found within the cytoskeleton. In contrast, recent work has revealed that the dynamic mechanical behavior of cells depends on generic system properties, rather than on a single molecular property of the cell. In this paper, we show that a mathematical model of cell mechanics that depicts the intracellular cytoskeleton as a tensegrity structure composed of a prestressed network of interconnected microfilaments, microtubules, and intermediate filaments, and that has previously explained static cellular properties, also can predict fundamental dynamic behaviors of living cells.

引用

页码：520 / 530

页数：11

共 40 条

[1] Microrheology of human lung epithelial cells measured by atomic force microscopy [J].