Novel 2,5-disubstituted-1H-pyrroles with high affinity for the dopamine D-3 receptor: N-benzyl modifications

被引：9

作者：

Boyfield, I ^{[1
]}

Coldwell, MC ^{[1
]}

Hadley, MS ^{[1
]}

Healy, MAM ^{[1
]}

Johnson, CN ^{[1
]}

Nash, DJ ^{[1
]}

Riley, GJ ^{[1
]}

Scott, EE ^{[1
]}

Smith, SA ^{[1
]}

Stemp, G ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT, HARLOW CM19 5AW, ESSEX, ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(96)00621-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2,5-disubstituted-1H-pyrroles (4-26) has been prepared where the conformational requirements of the N-ethyl, N-benzyl side-chain of 1 and the effect of introducing substituents into the benzyl group have been investigated. The (R)-alpha-methylbenzyl 6 and aminoindane 10 side-chains retained high affinity for the dopamine Dg receptor, although neither showed the selectivity of 2-phenylazacycloheptane 2. (C) 1997, Elsevier Science Ltd.

引用

页码：327 / 330

页数：4

共 5 条

[1] Novel 2,5-disubstituted-1H-pyrroles with high affinity for the dopamine D-3 receptor
Bolton, D
Boyfield, I
Coldwell, MC
Hadley, MS
Healy, MAM
Johnson, CN
Markwell, RE
Nash, DJ
Riley, GJ
Stemp, G
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[5] 2-PHENYLPYRROLES AS CONFORMATIONALLY RESTRICTED BENZAMIDE ANALOGS - A NEW CLASS OF POTENTIAL ANTIPSYCHOTICS .1.
VANWIJNGAARDEN, I
KRUSE, CG
VANHES, R
VANDERHEYDEN, JAM
TULP, MTM
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