Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind

被引：401

作者：

Yamaguchi, F

Ariga, T

Yoshimura, Y

Nakazawa, H

机构：

[1] Kikkoman Foods Inc, Div Res & Dev, Noda, Chiba 2780037, Japan

[2] Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, Tokyo 1428501, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2000年 / 48卷 / 02期

关键词：

Garcinia indica; garcinol; antioxidant; glycation;

D O I：

10.1021/jf990845y

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Garcinol, a polyisoprenylated benzophenone derivative, was purified from Garcinia indica fruit rind, and its antioxidative activity, chelating activity, free radical scavenging activity, and anti-glycation activity were studied. Garcinol exhibited moderate antioxidative activity in the micellar linoleic acid peroxidation system and also exhibited chelating activity at almost the same level as citrate. It also showed nearly 3 times greater DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging activity than DL-alpha-tocopherol by weight in aqueous ethanol solution. In a phenazine methosulfate/NADH-nitroblue tetrazolium system, garcinol exhibited superoxide anion scavenging activity and suppressed protein glycation in a bovine serum albumin/fructose system. Thus, garcinol might be beneficial as a potent antioxidant and a glycation inhibitor under specified conditions.

引用

页码：180 / 185

页数：6

共 33 条

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