Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene

被引：12

作者：

Adams, DJ

van der Weyden, L

Kovacic, A

Lovicu, F

Copeland, NG

Gilbert, DJ

Jenkins, NA

Ioannou, PA

Morris, BJ

机构：

[1] Univ Sydney, Dept Physiol, Gene Lab, Sydney, NSW 2006, Australia

[2] Univ Sydney, Inst Biomed Res F13, Sydney, NSW 2006, Australia

[3] SE Area Labs Serv, Dept Haematol, Cytogenet & Mol Genet Unit, Randwick, NSW, Australia

[4] NCI, Frederick Canc Res & Dev Ctr, Mammalian Genet Lab, ABL Basic Res Program, Frederick, MD 21702 USA

[5] Royal Childrens Hosp, Murdoch Inst, Melbourne, Vic, Australia

[6] Univ Sydney, Dept Anat & Histol, Sydney, NSW 2006, Australia

来源：

CYTOGENETICS AND CELL GENETICS | 2000年 / 88卷 / 1-2期

关键词：

D O I：

10.1159/000015487

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The chromosome location and pattern of expression of the gene encoding the zinc finger protein 265 (alias "Zis") in human (ZNF265) and mouse (Zfp265) was determined. By interspecific backcross analysis, we mapped Zfp265 to mouse chromosome 3q. ZNF265 was localized to human chromosome 1p31 by fluorescence in situ hybridization. Since discovery of Zfp265 (in rat) came from studies of changes in renin expression in kidney cell lines, we examined the cell specificity of expression in kidney and also determined hybridization of cDNA with RNA in other tissues. We Found that expression was not confined to renin mRNA-containing cells but was ubiquitous. Moreover, the fact that highly conserved homologs of ZNF265p exist in lower organisms (e.g., C4SR in Xenopus), suggests that this protein may have a generalized role in posttranscriptional mechanisms in various cell types and species, Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：68 / 73

页数：6

共 18 条

[1] Oligonucleotide-europium complex conjugate designed to cleave the 5′ cap structure of the ICAM-1 transcript potentiates antisense activity in cells [J].