Lanthanide-Doped LiLuF4 Upconversion Nanoprobes for the Detection of Disease Biomarkers

被引：475

作者：

Huang, Ping ^{[1
,2
,5
]}

Zheng, Wei ^{[1
,2
]}

Zhou, Shanyong ^{[3
,4
]}

Tu, Datao ^{[1
,2
]}

Chen, Zhuo ^{[3
,4
]}

Zhu, Haomiao ^{[1
,2
]}

Li, Renfu ^{[1
,2
]}

Ma, En ^{[1
,2
]}

Huang, Mingdong ^{[3
,4
]}

Chen, Xueyuan ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Key Lab Optoelect Mat Chem & Phys, Fujian Inst Res Struct Matter, Fuzhou 350002, Fujian, Peoples R China

[2] Chinese Acad Sci, Key Lab Design & Assembly Funct Nanostruct, Fujian Inst Res Struct Matter, Fuzhou 350002, Fujian, Peoples R China

[3] Chinese Acad Sci, State Key Lab Struct Chem, Fujian Inst Res Struct Matter, Fuzhou 350002, Fujian, Peoples R China

[4] Chinese Acad Sci, Danish Chinese Ctr Proteases & Canc, Fujian Inst Res Struct Matter, Fuzhou 350002, Fujian, Peoples R China

[5] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 05期

关键词：

biodetection; disease biomarkers; nanoprobes; LiLuF4; upconversion; UPCONVERTING NANOPARTICLES; EPITAXIAL-GROWTH; SHELL THICKNESS; NANOCRYSTALS; LUMINESCENCE; EXCITATION; DEPENDENCE; STRATEGY; DELIVERY;

D O I：

10.1002/anie.201309503

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Lanthanide-doped upconversion nanoparticles (UCNPs) have shown great promise in bioapplications. Exploring new host materials to realize efficient upconversion luminescence (UCL) output is a goal of general concern. Herein, we develop a unique strategy for the synthesis of novel LiLuF4:Ln(3+) core/shell UCNPs with typically high absolute upconversion quantum yields of 5.0% and 7.6% for Er3+ and Tm3+, respectively. Based on our customized UCL biodetection system, we demonstrate for the first time the application of LiLuF4:Ln(3+) core/shell UCNPs as sensitive UCL bioprobes for the detection of an important disease marker beta subunit of human chorionic gonadotropin (beta-hCG) with a detection limit of 3.8 ng mL(-1), which is comparable to the beta-hCG level in the serum of normal humans. Furthermore, we use these UCNPs in proof-of-concept computed tomography imaging and UCL imaging of cancer cells, thus revealing the great potential of LiLuF4:Ln(3+) UCNPs as efficient nano-bioprobes in disease diagnosis.

引用

页码：1252 / 1257

页数：6

共 38 条

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Luminescent Sensing of Oxygen Using a Quenchable Probe and Upconverting Nanoparticles [J].