Potential interaction between itraconazole and clarithromycin

被引:9
作者
Auclair, B
Berning, SE
Huitt, GA
Peloquin, CP
机构
[1] Natl Jewish Ctr Immunol & Resp Med, Dept Med, Denver, CO 80206 USA
[2] Univ Colorado, Sch Pharm, Denver, CO 80202 USA
[3] Univ Colorado, Sch Med, Denver, CO USA
来源
PHARMACOTHERAPY | 1999年 / 19卷 / 12期
关键词
D O I
10.1592/phco.19.18.1439.30907
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Three patients negative for human immunodeficiency virus infection were admitted for pulmonary Mycobacterium avium complex (MAC) and aspergillosis infections. They were treated with different drug combinations, but all regimens included clarithromycin for MAC and itraconazole for aspergillosis. All patients experienced an increase in clarithromycin concentrations and clarithromycin: 14-OH-clarithromycin ratio compared with expected range values. They had no clinical side effects. The time course suggested a possible interaction between clarithromycin and itraconazole, presumably through itraconazole's effects on cytochrome P450 3n4 activity. A bidirectional interaction cannot be ruled out. The data suggest that, when necessary, these two drugs can be administered together safely. Further investigation is necessary to determine the extent and clinical consequences of coadministration in humans.
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页码:1439 / 1444
页数:6
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