The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

被引：469

作者：

Gudmundsdottir, K. ^{[1
]}

Ashworth, A. ^{[1
]}

机构：

[1] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

ONCOGENE | 2006年 / 25卷 / 43期

关键词：

BRCA1; BRCA2; repair; genomic stability; DSS1;

D O I：

10.1038/sj.onc.1209874

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The BRCA1 and BRCA2 proteins are important in maintaining genomic stability by promoting efficient and precise repair of double-strand breaks. The main role of BRCA2 appears to involve regulating the function of RAD51 in the repair by homologous recombination. BRCA1 has a broader role upstream of BRCA2, participating in various cellular processes in response to DNA damage. The DNA repair defect associated with mutations in BRCA1 or BRCA2 could be exploited to develop new targeted therapeutic approaches for cancer occurring in mutation carriers.

引用

页码：5864 / 5874

页数：11

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