Endometrial glandular proliferation and estrogen receptor content during the normal menstrual cycle

被引:22
作者
Felix, JC
Farahmand, S
机构
[1] UNIV SO CALIF, SCH MED, DEPT PATHOL, LOS ANGELES, CA 90033 USA
[2] KAISER PERMANENTE HOSP, DEPT PATHOL, ANAHEIM, CA USA
关键词
estrogen receptor; endometrial proliferation; MIB-1;
D O I
10.1016/S0010-7824(96)00242-9
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Hysterectomy specimens from 35 normally cycling premenopausal women were examined to determine the relationship of endometrial glandular proliferation to estrogen receptor content. The cases were divided into follicular phase (n = 20), early luteal phase, days 1-5 post ovulation (n = 5), and mid to late luteal phase (n = 10). Proliferation rates, as determined by MIB-1 expression, were maximal in the endometrial functionalis during the follicular phase (701 cells/1000), decreased by half during the early luteal phase (327 cells/1000), and virtually ceased during the mid to late luteal phase (8 cells/1000) (p <0.001). Estrogen receptor status, determined immunohistochemically and graded on a scale of 0 to 4+, averaged 3.4+, 2.2+, and 0.5+ during the follicular, early luteal, and mid to late luteal phases, respectively, in the endometrial functionalis (p <0.001). Proliferation rates in the endometrial basalis paralleled those in the functionalis, but at a lower rate, whereas estrogen receptor expression underwent considerably less cyclical variation. We conclude that estrogen receptor status shows a highly significant correlation with glandular proliferation rates and are predictive of endometrial proliferative changes during the normal menstrual cycle. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:19 / 22
页数:4
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