Upgrading the BCL-2 network

被引：94

作者：

Galonek, Heidi L. ^{[1
]}

Hardwick, J. Marie ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

来源：

NATURE CELL BIOLOGY | 2006年 / 8卷 / 12期

关键词：

D O I：

10.1038/ncb1206-1317

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The BCL-2 oncogene promotes cancer progression by prohibiting cell death. BCL-2-related regulators were once thought to constitute a simple, two-class system of anti-death and pro-death factors. New data delineate a multistep hierarchy of BCL-2-family protein interactions that are driven by signal-dependent pathways.

引用

页码：1317 / 1319

页数：3

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