Single-molecule fluorescence studies of protein folding and conformational dynamics

被引：420

作者：

Michalet, Xavier ^{[1
]}

Weiss, Shimon ^{[1
]}

Jager, Marcus ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 05期

关键词：

D O I：

10.1021/cr0404343

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A review of single-molecule methods in chemistry is made to provide a rapid description of the main technical approaches. Topics discussed include fluorescence spectroscopy as a tool for molecular conformation and fluctuation measurements, single-molecule data acquisition and analysis methods, data analysis methods, single-molecule fluorescence studies of protein folding and conformations at equilibrium, and single-molecule protein folding under nonequilibrium conditions.

引用

页码：1785 / 1813

页数：29

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