Migraine and tumour necrosis factor gene polymorphism

被引：27

作者：

Asuni, C. ^{[1
]}

Stochino, M. E. ^{[1
]}

Cherchi, A. ^{[1
]}

Manchia, M. ^{[1
]}

Congiu, D. ^{[1
]}

Manconi, F. ^{[1
]}

Squassina, A. ^{[1
]}

Piccardi, M. P. ^{[1
]}

Del Zompo, Maria ^{[1
]}

机构：

[1] Univ Cagliari, Headache Ctr Franco Tocco, Clin Pharmacol Sect, Bb Brodie Dept Neurosci, I-09124 Cagliari, Italy

来源：

JOURNAL OF NEUROLOGY | 2009年 / 256卷 / 02期

关键词：

migraine; tumour necrosis factor; polymorphism; HLA; gene; ALPHA GENE;

D O I：

10.1007/s00415-009-0961-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

To assess the possibility of an association between TNF gene polymorphisms and migraine without aura, a case-control study was performed in a Sardinian sample. Migraine without aura is a complex genetic disease in which susceptibility and environmental factors contribute towards its development. Several studies suggest that tumour necrosis factors (TNF) (TNF-alpha and lymphotoxin-alpha or TNF-A) may be involved in the pathophysiology of migraine. The TNF-alpha and TNF-A genes are located on chromosome 6p21.3 in the human leukocyte antigene (HLA) class III region. We evaluated 299 patients affected by migraine without aura (I.H.S. criteria 2004) and 278 migraine-free controls. The polymorphisms G308A of the TNF- alpha gene, and G252A of TNF-beta gene were determined by NcoI restriction fragment length polymorphism analysis. We found a statistically significant difference in allele (p = 0.018; OR = 1.46 95 % CI: 1.066 to 2.023) and genotype (trend chi 2 = 5.46, df = 1, p = 0.019) frequencies of TNF-beta gene, between cases and controls. Allele and genotype frequencies of TNF-alpha polymorphism did not differ significantly between the two groups. These data suggest that subjects with the TNFB2 allele have a low risk of developing migraine without aura and/or that the polymorphism of the TNF-beta gene is in linkage disequilibrium with other migraine responsible genes in the HLA region.

引用

页码：194 / 197

页数：4

共 14 条

[1]

Genetics of population isolates [J].