Growth factors in lung development and disease: friends or foe?

被引：47

作者：

Desai, TJ ^{[1
]}

Cardoso, WV ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA

来源：

RESPIRATORY RESEARCH | 2001年 / 3卷 / 01期

关键词：

airway branching; growth factors; lung development; lung injury-repair;

D O I：

10.1186/rr169

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung. Altered expression of growth factors, such as transforming growth factor beta1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions. In this paper, we discuss the dual role of these molecules in mediating beneficial feedback responses or responses that can further damage lung integrity; we shall also discuss the basis for their prospective use as therapeutic agents.

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页数：4

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