Effects of roxithromycin and erythromycin on interleukin 8-induced neutrophil recruitment and goblet cell secretion in guinea pig tracheas

被引：22

作者：

Tamaoki, J

Nakata, J

Tagaya, E

Konno, K

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 07期

关键词：

D O I：

10.1128/AAC.40.7.1726

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Inhaled interleukin 8 caused an increase in goblet cell secretion in guinea pig tracheas, which was accompanied by mucosal infiltration of neutrophils, These responses were inhibited by pretreatment with roxithromycin or erythromycin in a dose-dependent fashion, Macrolides may thus be of value in protecting against neutrophil-associated airway hypersecretion.

引用

页码：1726 / 1728

页数：3

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