Caspase-8 in cancer biology and therapy

被引：148

作者：

Fulda, Simone ^{[1
]}

机构：

[1] Univ Childrens Hosp, D-89075 Ulm, Germany

来源：

CANCER LETTERS | 2009年 / 281卷 / 02期

关键词：

Apoptosis; Caspase-8; Cancer; SENSITIVE RESPONSE ELEMENT; TRAIL-MEDIATED APOPTOSIS; BREAST-TUMOR CELLS; INTERFERON-GAMMA; NEUROBLASTOMA-CELLS; IFN-GAMMA; GENE-EXPRESSION; DEATH RECEPTOR; UP-REGULATION; EWINGS-SARCOMA;

D O I：

10.1016/j.canlet.2008.11.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Caspase-8 belongs to the caspase family of proteases and plays a key role in the regulation of programmed cell death (apoptosis) during normal development as well as in adult life. Since signaling via the death receptor (extrinsic) pathway critically depends on caspase-8, the disturbance of caspase-8 expression or function may contribute to human diseases. For example, caspase-8 is inactivated in a variety of human cancers, which may promote tumor progression as well as resistance to current treatment approaches. Therefore, caspase-8 presents a promising target to restore defective apoptosis programs in cancels in order to overcome resistance. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

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收藏

页码：128 / 133

页数：6

相关论文

共 77 条

[1]

The Bcl-2 apoptotic switch in cancer development and therapy [J].

Adams, J. M. ;

Cory, S. .

ONCOGENE, 2007, 26 (09) :1324-1337

[2]

Apoptosis-independent functions of killer caspases [J].

Algeciras-Schimnich, A ;

Barnhart, BC ;

Peter, ME .

CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (06) :721-726

[3]

Targeting the extrinsic apoptosis pathway in cancer [J].

Ashkenazi, Avi .

CYTOKINE & GROWTH FACTOR REVIEWS, 2008, 19 (3-4) :325-331

[4]

Identification of a critical tyrosine residue in caspase 8 that promotes cell migration [J].

Barbero, Simone ;

Barila, Daniela ;

Mielgo, Ainhoa ;

Stagni, Venturina ;

Clair, Kiran ;

Stupack, Dwayne .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (19) :13031-13034

[5]

The death effector domain protein family [J].

Barnhart, BC ;

Lee, JC ;

Alappat, EC ;

Peter, ME .

ONCOGENE, 2003, 22 (53) :8634-8644

[6]

Mechanisms of caspase activation [J].

Boatright, KM ;

Salvesen, GS .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (06) :725-731

[7]

Caspase-8 gene expression in neuroblastoma [J].

Casciano, I ;

Banelli, B ;

Croce, M ;

De Ambrosis, A ;

Di Vinci, A ;

Gelvi, I ;

Pagnan, G ;

Brignole, C ;

Allemanni, G ;

Ferrini, S ;

Ponzoni, M ;

Romani, M .

SIGNAL TRANSDUCTION AND COMMUNICATION IN CANCER CELLS, 2004, 1028 :157-167

[8]

Expression of the caspase-8 gene in neuroblastoma cells is regulated through an essential interferon-sensitive response element (ISRE) [J].

Casciano, I ;

De Ambrosis, A ;

Croce, M ;

Pagnan, G ;

Di Vinci, A ;

Allemanni, G ;

Banelli, B ;

Ponzoni, M ;

Romani, M ;

Ferrini, S .

CELL DEATH AND DIFFERENTIATION, 2004, 11 (01) :131-134

[9]

Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway:: Absolute requirement for removal of caspase-6 prodomain [J].

Cowling, V ;

Downward, J .

CELL DEATH AND DIFFERENTIATION, 2002, 9 (10) :1046-1056

[10]

Src kinase phosphorylates caspase-8 on Tyr380:: a novel mechanism of apoptosis suppression [J].

Cursi, Silvia ;

Rufini, Alessandra ;

Stagni, Venturina ;

Condo, Ivano ;

Matafora, Vittoria ;

Bachi, Angela ;

Bonifazi, Antonio Paniccia ;

Coppola, Luigi ;

Superti-Furga, Giulio ;

Testi, Roberto ;

Barila, Daniela .

EMBO JOURNAL, 2006, 25 (09) :1895-1905

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