Bax and Bak: back-bone of T cell death

被引：16

作者：

Bouillet, P ^{[1
]}

Strasser, A ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

NATURE IMMUNOLOGY | 2002年 / 3卷 / 10期

关键词：

D O I：

10.1038/ni1002-893

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptosis shapes T cell development and immune responses. The pro-apoptotic molecules Bax and Bak have overlapping essential functions in T cell development and homeostasis.

引用

页码：893 / 894

页数：3

共 12 条

[1] Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
Bouillet, P
Metcalf, D
Huang, DCS
Tarlinton, DM
Kay, TWH
Köntgen, F
Adams, JM
Strasser, A
[J]. SCIENCE, 1999, 286 (5445) : 1735 - 1738
[2] BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
Bouillet, P
Purton, JF
Godfrey, DI
Zhang, LC
Coultas, L
Puthalakath, H
Pellegrini, M
Cory, S
Adams, JM
Strasser, A
[J]. NATURE, 2002, 415 (6874) : 922 - 926
[3] BCL-2, BCL-XL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
Cheng, EHYA
Wei, MC
Weiler, S
Flavell, RA
Mak, TW
Lindsten, T
Korsmeyer, SJ
[J]. MOLECULAR CELL, 2001, 8 (03) : 705 - 711
[4] Activated T cell death in vivo mediated by proapoptotic Bcl-2 family member Bim
Hildeman, DA
Zhu, YN
Mitchell, TC
Bouillet, P
Strasser, A
Kappler, J
Marrack, P
[J]. IMMUNITY, 2002, 16 (06) : 759 - 767
[5] BH3-Only proteins - Essential initiators of apoptotic cell death
Huang, DCS
Strasser, A
[J]. CELL, 2000, 103 (06) : 839 - 842
[6] The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues
Lindsten, T
Ross, AJ
King, A
Zong, WX
Rathmell, JC
Shiels, HA
Ulrich, E
Waymire, KG
Mahar, P
Frauwirth, K
Chen, YF
Wei, M
Eng, VM
Adelman, DM
Simon, MC
Ma, A
Golden, JA
Evan, G
Korsmeyer, SJ
MacGregor, GR
Thompson, CB
[J]. MOLECULAR CELL, 2000, 6 (06) : 1389 - 1399
[7] BCL-2 IS UP-REGULATED AT THE CD4(+)CD8(+) STAGE DURING POSITIVE SELECTION AND PROMOTES THYMOCYTE DIFFERENTIATION AT SEVERAL CONTROL POINTS
LINETTE, GP
GRUSBY, MJ
HEDRICK, SM
HANSEN, TH
GLIMCHER, LH
KORSMEYER, SJ
[J]. IMMUNITY, 1994, 1 (03) : 197 - 205
[8] Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
Rathmell, JC
Lindsten, T
Zong, WX
Cinalli, RM
Thompson, CB
[J]. NATURE IMMUNOLOGY, 2002, 3 (10) : 932 - 939
[9] NOVEL PRIMITIVE LYMPHOID TUMORS INDUCED IN TRANSGENIC MICE BY COOPERATION BETWEEN MYC AND BCL-2
STRASSER, A
HARRIS, AW
BATH, ML
CORY, S
[J]. NATURE, 1990, 348 (6299) : 331 - 333
[10] BCL-2 EXPRESSION PROMOTES B-LYMPHOID BUT NOT T-LYMPHOID DEVELOPMENT IN SCID MICE
STRASSER, A
HARRIS, AW
CORCORAN, LM
CORY, S
[J]. NATURE, 1994, 368 (6470) : 457 - 460

← 1 2 →