Advances in gene targeting methods

被引：34

作者：

Kuhn, R

Schwenk, F

机构：

[1] Institute for Genetics, Dept. Immunol., Weyertal 121, 50931, Cologne

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(97)80133-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gene targeting in embryonic stem cells is commonly used for gene inactivation and the generation of mouse mutants. The combined use of methods for site-specific and homologous DNA recombination expands the potential of gene targeting in embryonic stem cells considerably and offers the opportunity of conditional gene targeting in mice.

引用

收藏

页码：183 / 188

页数：6

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