Disturbance of rat lever-press learning by hippocampo-prefrontal disconnection

被引：38

作者：

Izaki, Y ^{[1
]}

Hori, K ^{[1
]}

Nomura, M ^{[1
]}

机构：

[1] Saitama Med Sch, Dept Physiol, Iruma, Saitama 3500495, Japan

来源：

BRAIN RESEARCH | 2000年 / 860卷 / 1-2期

关键词：

prefrontal cortex; hippocampus; operant learning; lever-press; lidocaine; rat;

D O I：

10.1016/S0006-8993(00)02039-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine whether the medial prefrontal cortex (PFC), ventral hippocampus and hippocampo-PFC pathway are involved in operant lever-press learning, we conducted lidocaine injections to these brain sites. Rats were injected immediately after lever-press acquisition in the first training, and the second 5-min test the next day. Results showed the response rate of either PFC- or ventral hippocampus-inactivated rats to be lower than that of control rats in the test the next day. Rats having lidocaine injected into the unilateral ventral hippocampus combined with contralateral medial PFC also showed lower response rate in their tests. These results suggest that hippocampo-PFC disconnection disturbs operant learning. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：199 / 202

页数：4

共 17 条

[1] A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].

BLISS, TVP ;

COLLINGRIDGE, GL .

NATURE, 1993, 361 (6407) :31-39

[2] LONG-TERM POTENTIATION OF HIPPOCAMPAL AFFERENTS AND EFFERENTS TO PREFRONTAL CORTEX - IMPLICATIONS FOR ASSOCIATIVE LEARNING [J].

DOYERE, V ;

BURETTE, F ;

REDINIDELNEGRO, C ;

LAROCHE, S .

NEUROPSYCHOLOGIA, 1993, 31 (10) :1031-1053

[3]

Floresco SB, 1997, J NEUROSCI, V17, P1880

[4]

Hock BJ, 1998, J NEUROSCI, V18, P7027

[5] Dopamine and acetylcholine elevation on lever-press acquisition in rat prefrontal cortex [J].

Izaki, Y ;

Hori, K ;

Nomura, M .

NEUROSCIENCE LETTERS, 1998, 258 (01) :33-36

[6] SELECTIVITY OF THE HIPPOCAMPAL PROJECTION TO THE PRELIMBIC AREA OF THE PREFRONTAL CORTEX IN THE RAT [J].

JAY, TM ;

GLOWINSKI, J ;

THIERRY, AM .

BRAIN RESEARCH, 1989, 505 (02) :337-340

[7]

JUNG MW, 1994, J NEUROSCI, V14, P7347

[8] Firing characteristics of deep layer neurons in prefrontal cortex in rats performing spatial working memory tasks [J].

Jung, MW ;

Qin, YL ;

McNaughton, BL ;

Barnes, CA .

CEREBRAL CORTEX, 1998, 8 (05) :437-450

[9]

Knight RT, 1998, REV NEUROSCIENCE, V9, P57

[10] FUNCTIONS OF THE FRONTAL-CORTEX OF THE RAT - A COMPARATIVE REVIEW [J].

KOLB, B .

BRAIN RESEARCH REVIEWS, 1984, 8 (01) :65-98

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