Antiviral defense: RIG-Ing the immune system to STING

被引：14

作者：

Bowzard, J. Bradford ^{[1
]}

Ranjan, Priya ^{[1
]}

Sambhara, Suryaprakash ^{[1
]}

Fujita, Takashi ^{[2
]}

机构：

[1] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA

[2] Kyoto Univ, Inst Virus Res, Mol Genet Lab, Dept Genet & Mol Biol, Kyoto 606, Japan

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2009年 / 20卷 / 01期

关键词：

RIG-I; Type I interferon; Virus; Cytosolic pathogen sensors; RNA; RECOGNITION; RESPONSES;

D O I：

10.1016/j.cytogfr.2009.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A critical component of the innate immune response is the presence of germ line-encoded receptors capable of recognizing a wide variety of pathogen-associated molecules. One group of these receptors, the cytoplasmic RIG-I-like helicases (RLH), is involved in the induction of Type I interferon in response to viral infection. Here we discuss results of recent investigations into the initiation and transmission of signals through the RIG-I pathway. Published by Elsevier Ltd.

引用

页码：1 / 5

页数：5

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