Everolimus

被引：64

作者：

Atkins, Michael B. ^{[1
]}

Yasothan, Uma ^{[2
]}

Kirkpatrick, Peter

机构：

[1] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[2] IMS Hlth, London NW1 6JB, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2009年 / 8卷 / 07期

关键词：

RAPAMYCIN;

D O I：

10.1038/nrd2924

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In March 2009, everolimus (Afinitor; Novartis), an inhibitor of mTOR, was approved by the US FDA for the treatment of patients with advanced kidney cancer.

引用

页码：535 / 536

页数：2

共 12 条

[1]

ATKINS MB, 2009, CANCER, V115, pS2247

[2] Renal-cell carcinoma [J].

Cohen, HT ;

McGovern, FJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (23) :2477-2490

[3] Current development of mTOR inhibitors as anticancer agents [J].

Faivre, Sandrine ;

Kroemer, Guido ;

Raymond, Eric .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (08) :671-688

[4]

Food and Drug Administration, 2009, FDA LAB INF

[5] Recent progress in the management of advanced renal cell carcinoma [J].

Garcia, Jorge A. ;

Rini, Brian I. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2007, 57 (02) :112-125

[6]

HAUBER A, JP MORGAN EUROPEAN E

[7] mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor [J].

Lane, Heidi A. ;

Wood, Jeanette M. ;

McSheehy, Paul M. J. ;

Allegrini, Peter R. ;

Boulay, Anne ;

Brueggen, Joseph ;

Littlewood-Evans, Amanda ;

Maira, Sauveur-Michel ;

Martiny-Baron, Georg ;

Schnell, Christian R. ;

Sini, Patrizia ;

O'Reilly, Terence .

CLINICAL CANCER RESEARCH, 2009, 15 (05) :1612-1622

[8] Efficacy of everolimus in advanced renal cell carcinoma:: a double-blind, randomised, placebo-controlled phase III trial [J].

Motzer, Robert J. ;

Escudier, Bernard ;

Oudard, Stephane ;

Hutson, Thomas E. ;

Porta, Camillo ;

Bracarda, Sergio ;

Gruenwald, Viktor ;

Thompson, John A. ;

Figlin, Robert A. ;

Hollaender, Norbert ;

Urbanowitz, Gladys ;

Berg, William J. ;

Kay, Andrea ;

Lebwohl, David ;

Ravaud, Alain .

LANCET, 2008, 372 (9637) :449-456

[9] Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma [J].

Motzer, Robert J. ;

Hutson, Thomas E. ;

Tomczak, Piotr ;

Michaelson, M. Dror ;

Bukowski, Ronald M. ;

Oudard, Stephane ;

Negrier, Sylvie ;

Szczylik, Cezary ;

Pili, Roberto ;

Bjarnason, Georg A. ;

Garcia-del-Muro, Xavier ;

Sosman, Jeffrey A. ;

Solska, Ewa ;

Wilding, George ;

Thompson, John A. ;

Kim, Sindy T. ;

Chen, Isan ;

Huang, Xin ;

Figlin, Robert A. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (22) :3584-3590

[10] Temsirolimus [J].

Rini, Brian ;

Kar, Santwana ;

Kirkpatrick, Peter .

NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (08) :599-600

← 1 2 →