A Raf-induced, MEK-independent signaling pathway regulates atrial natriuretic factor gene expression in cardiac muscle cells

被引:14
作者
Jette, C [1 ]
Thorburn, A [1 ]
机构
[1] Univ Utah, Dept Oncol Sci, Huntsman Canc Inst, Salt Lake City, UT 84112 USA
来源
FEBS LETTERS | 2000年 / 467卷 / 01期
关键词
atrial natriuretic factor; MEK-independent Raf signaling; cardiac myocyte; MAP kinase;
D O I
10.1016/S0014-5793(00)01114-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The atrial natriuretic factor (ANF) gene is activated in cardiac myocytes by Ras and its effector Raf. However, MEK, the best-characterized Raf substrate, cannot efficiently activate ANF suggesting that Raf uses a MEK-independent pathway to activate ANF. By manipulating MEK and Raf activities so that they are equally effective at activating ERK, we now demonstrate that Raf activates at least two signaling pathways in cardiac myocytes that regulate the ANF promoter; the MEK-->ERK pathway inhibits ANF gene expression while a Raf-induced, MEK-independent pathway activates expression. This mechanism may provide increased ability to regulate ANF expression in response to hypertrophic stimuli. (C) 2000 Federation of European Biochemical Societies.
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页码:1 / 6
页数:6
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