Presence of glomerular basement membrane (GBM) antibodies in HIV- patients with Pneumocystis carinii pneumonia

被引:15
作者
Calderon, EJ
Wichmann, I
Varela, JM
Respaldiza, N
Regordan, C
FernandezAlonso, J
Medrano, FJ
Cano, S
Cuello, JA
NunezRoldan, A
机构
[1] HOSP UNIV VIRGEN ROCIO,SERV IMMUNOL,DEPT MED,SEVILLE 41013,SPAIN
[2] HOSP UNIV VIRGEN ROCIO,MICROBIOL SERV,SEVILLE 41013,SPAIN
[3] HOSP UNIV VIRGEN ROCIO,SERV ANAT PATOL,SEVILLE 41013,SPAIN
关键词
Pneumocystis carinii; Goodpasture's syndrome; glomerular basement membrane antibodies;
D O I
10.1046/j.1365-2249.1997.d01-969.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Following the unexpected finding of antibodies to GEM in a patient with Pneumocystis carinii pneumonia in the absence of kidney abnormalities, the presence of anti-GEM antibodies was analysed in 14 patients with pulmonary P. carinii infection who did not have clinical evidence of autoimmune glomerulonephritis. Patients were divided into three groups: HIV- with P. carinii pneumonia (n = 4), HIV+ with P. carinii pneumonia (n = 5) and HIV- carriers of P. carinii without pneumonia (n = 5). As control groups, HN - patients with community-acquired non-P. carinii pneumonia (n = 6) and healthy individuals (n = 16) were included. Anti-GEM antibodies, studied with a quantitative enzyme immuno-assay (EIA) for anti-alpha 3 chain of collagen IV antibodies, were detected in three out of the four HIV- patients with P. carinii pneumonia, but not in any individuals of the other categories. These results suggest that P. carinii alveolar injury or the host response to the organism could affect the basal membrane Goodpasture antigen or a similar antigen, and induces anti-GEM antibody production in HIV- patients, and support the hypothesis that, at least in some cases, Goodpasture's syndrome could be triggered by an alveolar lesion induced by a P. carinii pneumonia.
引用
收藏
页码:448 / 450
页数:3
相关论文
共 15 条
[1]   Pneumocystis carinii infection in patients with chronic bronchial disease [J].
Calderon, EJ ;
Regordan, C ;
Medrano, FJ ;
Ollero, M ;
Varela, JM .
LANCET, 1996, 347 (9006) :977-977
[2]   PNEUMOCYSTIS-CARINII PNEUMONIA IN PATIENTS WITHOUT PREDISPOSING ILLNESSES - ACUTE EPISODE AND FOLLOW-UP OF 5 CASES [J].
CANO, S ;
CAPOTE, F ;
PEREIRA, A ;
CALDERON, E ;
CASTILLO, J .
CHEST, 1993, 104 (02) :376-381
[3]  
HUDSON BG, 1989, LAB INVEST, V61, P256
[4]   A CLUSTER OF PNEUMOCYSTIS-CARINII PNEUMONIA IN ADULTS WITHOUT PREDISPOSING ILLNESSES [J].
JACOBS, JL ;
LIBBY, DM ;
WINTERS, RA ;
GELMONT, DM ;
FRIED, ED ;
HARTMAN, BJ ;
LAURENCE, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (04) :246-250
[5]   THE ALPHA-3 CHAIN OF TYPE-IV COLLAGEN INDUCES AUTOIMMUNE GOODPASTURE-SYNDROME [J].
KALLURI, R ;
GATTONE, VH ;
NOELKEN, ME ;
HUDSON, BG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :6201-6205
[6]   EVIDENCE FOR SHARED EPITOPES BETWEEN CARDIOLIPIN AND PNEUMOCYSTIS-CARINII [J].
MASALA, C ;
SORICE, M ;
DIPRIMA, MA ;
LENTI, L ;
MISASI, R ;
MOJON, M ;
CONTINI, C ;
VULLO, V .
JOURNAL OF INFECTIOUS DISEASES, 1989, 160 (04) :736-737
[7]   ANTICARDIOLIPIN ANTIBODIES AND PNEUMOCYSTIS-CARINII PNEUMONIA [J].
MASALA, C ;
SORICE, M ;
DIPRIMA, MA ;
LENTI, L ;
MISASI, R ;
CONTINI, C ;
VULLO, V .
ANNALS OF INTERNAL MEDICINE, 1989, 110 (09) :749-749
[8]   IMMUNOLOGICAL ABNORMALITIES IN HUMAN IMMUNODEFICIENCY VIRUS (HIV)-INFECTED ASYMPTOMATIC HOMOSEXUAL MEN - HIV AFFECTS THE IMMUNE-SYSTEM BEFORE CD4+ T-HELPER CELL DEPLETION OCCURS [J].
MIEDEMA, F ;
PETIT, AJC ;
TERPSTRA, FG ;
SCHATTENKERK, JKME ;
DEWOLF, F ;
AL, BJM ;
ROOS, M ;
LANGE, JMA ;
DANNER, SA ;
GOUDSMIT, J ;
SCHELLEKENS, PTA .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (06) :1908-1914
[9]   SURFACTANT PROTEIN-D INTERACTS WITH PNEUMOCYSTIS-CARINII AND MEDIATES ORGANISM ADHERENCE TO ALVEOLAR MACROPHAGES [J].
ORIORDAN, DM ;
STANDING, JE ;
KWON, KY ;
CHANG, D ;
CROUCH, EC ;
LIMPER, AH .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (06) :2699-2710
[10]  
Peebles R S, 1990, J Tenn Med Assoc, V83, P80