Investigation of hormonal male contraception in African men: suppression of spermatogenesis by oral desogestrel with depot testosterone

被引:33
作者
Anderson, RA [1 ]
van der Spuy, ZM
Dada, OA
Tregoning, SK
Zinn, PM
Adeniji, OA
Fakoya, TA
Smith, KB
Baird, DT
机构
[1] MRC, Ctr Reprod Biol, Human Reprod Sci Unit, Contracept Dev Network, Edinburgh EH16 4SB, Midlothian, Scotland
[2] Univ Cape Town, Dept Obstet & Gynaecol, Contracept Dev Network, ZA-7925 Cape Town, South Africa
[3] Ctr Res Reprod Hlth, Contracept Dev Network, Shagamu, Nigeria
[4] Univ Edinburgh, Ctr Reprod Biol, Div Reprod Sci & Dev, Contracept Dev Network, Edinburgh EH16 4SB, Midlothian, Scotland
关键词
depot testosterone; desogestrol; male contraception; spermatogenesis;
D O I
10.1093/humrep/17.11.2869
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: Suppression of spermatogenesis to azoospermia is required for effective hormonal male contraception, but the degree of suppression varies between ethnic groups. We here report the first study of hormonal suppression of spermatogenesis in two African centres using a regimen of oral progestogen with depot testosterone. METHODS A total of 31 healthy men (21 black) were recruited in Cape Town and 21 men in Sagamu, Nigeria. Subjects were randomized to take either 150 or 300 mug desogestrel daily p.o. with testosterone pellets. In Cape Town, desogestrel was administered for 24 weeks with 400 mg testosterone re-administered 12 weekly. In Sagamu, desogestrel was administered for 52 weeks with 200 mg testosterone (later increased to 400 mg) re-administered 12-weekly. RESULTS: In Cape Town, 22 men completed at least 20 weeks treatment. Azoospermia was achieved in 8/10 and 8/12 men in the 150 mug and 300 mug desogestrel groups. Four men in Sagamu withdrew. Azoospermia was achieved in all 17 men in the two groups. There were no significant changes in lipoprotein or haemoglobin concentrations in any group. CONCLUSION: These data demonstrate that the combination of oral desogestrel with depot testosterone is an effective regimen for suppression of spermatogenesis in African as in Caucasian and Chinese men, with azoospermia achieved in a total of 83/98 (85%) men.
引用
收藏
页码:2869 / 2877
页数:9
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