Female predominance and X chromosome defects in autoimmune diseases

被引：140

作者：

Invernizzi, Pietro ^{[1
,2
,4
]}

Pasini, Simone ^{[1
,2
,3
]}

Selmi, Carlo ^{[1
,2
,3
,4
]}

Gershwin, M. Eric ^{[4
]}

Podda, Mauro ^{[1
,2
,3
]}

机构：

[1] IRCCS Ist Clin Humanitas, Hepatobiliary Immunopathol Unit, I-20089 Milan, Italy

[2] IRCCS Ist Clin Humanitas, Div Internal Med, I-20089 Milan, Italy

[3] Univ Milan, Dept Translat Med, Milan, Italy

[4] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA

来源：

JOURNAL OF AUTOIMMUNITY | 2009年 / 33卷 / 01期

关键词：

Genetic factors; Female preponderance; Etiopathogenesis; Sex chromosomes; Autoimmune disease; SYSTEMIC-LUPUS-ERYTHEMATOSUS; PRIMARY BILIARY-CIRRHOSIS; WISKOTT-ALDRICH-SYNDROME; FETAL MICROCHIMERISM; THYROID AUTOIMMUNITY; INACTIVATION RATIOS; MULTIPLE-SCLEROSIS; BLOOD-CELLS; T-CELLS; WOMEN;

D O I：

10.1016/j.jaut.2009.03.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is known that autoimmune diseases cumulatively affect 5-10% of the general population. Although knowledge of pathogenesis has become more refined, laboratory diagnosis more accurate, and therapy more effective, the reasons for the female preponderance of these conditions remain unclear. The most intriguing theory to explain the female preponderance is currently related to sex chromosomes, as women with autoimmune diseases manifest a higher rate of circulating cells with a single X chromosome (i.e. X monosomy). In addition, there have been several reports on the role of X chromosome gene dosage through inactivation or duplication in autoimmunity. Taken together, sex chromosome changes might constitute the common trait of the susceptibility to autoimmune diseases. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：12 / 16

页数：5

共 62 条

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