Differential immunogenicity of HLA class I alloantigens for the humoral versus the cellular immune response: "Towards tailor-made HLA mismatching"'

被引：12

作者：

Claas, FHJ

Roelen, DL

Mulder, A

Doxiadis, IIN

Oudshoorn, M

Heemskerk, M

机构：

[1] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2300 RC Leiden, Netherlands

[2] Europdonor Fdn, Leiden, Netherlands

来源：

HUMAN IMMUNOLOGY | 2006年 / 67卷 / 06期

关键词：

D O I：

10.1016/j.humimm.2006.03.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunogenicity of an individual human leukocyte antigen (HLA) class I mismatch is different for the cellular and the humoral alloimmune responses. The consequence is that the same antigen can induce a strong antibody response and no cytotoxic T lymphocyte reactivity, but the reverse can occur also. Exact knowledge of the immunogenicity of an HLA mismatch for an individual patient can lead to a strategy of tailor-made HLA mismatching if no HLA identical donor is available. Depending on the clinical situation, one should select a donor with HLA mismatches according to the humoral or cellular mismatch algorithm.

引用

页码：424 / 429

页数：6

共 35 条

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