Genetic vulnerability to drug abuse

被引：25

作者：

Duaux, E ^{[1
]}

Krebs, MO ^{[1
]}

Loo, H ^{[1
]}

Poirier, MF ^{[1
]}

机构：

[1] Hop St Anne, Serv Hosp Univ Sante Mentale & Therapeut, F-75014 Paris, France

来源：

EUROPEAN PSYCHIATRY | 2000年 / 15卷 / 02期

关键词：

addiction; allele; association; drug abuse; genetics; polymorphism;

D O I：

10.1016/S0924-9338(00)00204-2

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Addiction to various substances, including drugs and alcohol, probably arises from a combination of environmental and genetic factors. The genetic vulnerability to drug addiction is supported by several familiar, adoption and twin studies. However, as in other mental disorders, the genetic vulnerability to drug addiction appears complex: these disorders do not follow the rules of Mendelian inheritance. Instead, they are probably influenced by multiple susceptibility genes, each of which contributes to the disorder. The more genes necessary for a disorder, the harder it is to detect any of them. This difficulty is magnified by the role of environmental factors. Association studies using the candidate gene approach can identify susceptibility genes for drug abuse supported by the pathophysiological hypothesis of the illness. This review will focus on the clinical and molecular genetic studies in drug abuse. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：109 / 114

页数：6

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