The GDNF family: Signalling, biological functions and therapeutic value

被引：1435

作者：

Airaksinen, MS ^{[1
]}

Saarma, M ^{[1
]}

机构：

[1] Univ Helsinki, Viikki Bioctr, Inst Biotechnol, Programme Mol Neurobiol, FIN-00014 Helsinki, Finland

来源：

NATURE REVIEWS NEUROSCIENCE | 2002年 / 3卷 / 05期

基金：

芬兰科学院;

关键词：

D O I：

10.1038/nrn812

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Members of the nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) families - comprising neurotrophins and GDNF-family ligands (GFLs), respectively - are crucial for the development and maintenance of distinct sets of central and peripheral neurons. Knockout studies in the mouse have revealed that members of these two families might collaborate or act sequentially in a given neuron. Although neurotrophins and GFLs activate common intracellular signalling pathways through their receptor tyrosine kinases, several clear differences exist between these families of trophic factors.

引用

页码：383 / 394

页数：12

共 88 条

[1] GDNF family neurotrophic factor signaling: Four masters, one servant?
Airaksinen, MS
Titievsky, A
Saarma, M
[J]. MOLECULAR AND CELLULAR NEUROSCIENCE, 1999, 13 (05) : 313 - 325
[2] Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease
Åkerud, P
Canals, JM
Snyder, EY
Arenas, E
[J]. JOURNAL OF NEUROSCIENCE, 2001, 21 (20) : 8108 - 8118
[3] Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons
Åkerud, P
Alberch, J
Eketjäll, S
Wagner, J
Arenas, E
[J]. JOURNAL OF NEUROCHEMISTRY, 1999, 73 (01) : 70 - 78
[4] GDNF rescues nonpeptidergic unmyelinated primary afferents in streptozotocin-treated diabetic mice
Akkina, SK
Patterson, CL
Wright, DE
[J]. EXPERIMENTAL NEUROLOGY, 2001, 167 (01) : 173 - 182
[5] Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site
Anders, J
Kjær, S
Ibáñez, CF
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (38) : 35808 - 35817
[6] Andres R, 2001, DEVELOPMENT, V128, P3685
[7] Arce V, 1998, J NEUROSCI, V18, P1440
[8] Stroke induces widespread changes of gene expression for glial cell line-derived neurotrophic factor family receptors in the adult rat brain
Arvidsson, A
Kokaia, Z
Airaksinen, MS
Saarma, M
Lindvall, O
[J]. NEUROSCIENCE, 2001, 106 (01) : 27 - 41
[9] Double heterozygosity for a RET substitution interfering with splicing and an EDNRB missense mutation in Hirschsprung disease
Auricchio, A
Griseri, P
Carpentieri, ML
Betsos, N
Staiano, A
Tozzi, A
Priolo, M
Thompson, H
Bocciardi, R
Romeo, G
Ballabio, A
Ceccherini, I
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 64 (04) : 1216 - 1221
[10] Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRα1 RET-specific agonists
Baloh, RH
Tansey, MG
Johnson, EM
Milbrandt, J
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (05) : 3412 - 3420

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