A syntenin-like protein with postsynaptic density protein (PDZ) domains produced by black tiger shrimp Penaeus monodon in response to white spot syndrome virus infection

被引：25

作者：

Bangrak, P

Graidist, P

Chotigeat, W

Supamattaya, K

Phongdara, A ^{[1
]}

机构：

[1] Prince Songkla Univ, Fac Sci, Dept Biochem, Hat Yai 90110, Thailand

[2] Prince Songkla Univ, Fac Agroind, Dept Biotechnol, Songkhla 90110, Taiwan

[3] Prince Songkla Univ, Fac Nat Sci, Dept Aquat Sci, Songkhla 90110, Taiwan

来源：

DISEASES OF AQUATIC ORGANISMS | 2002年 / 49卷 / 01期

关键词：

white spot syndrome virus; Penaeus monodon; signal transduction; syntenin; postsynaptic density protein; PDZ;

D O I：

10.3354/dao049019

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

We report the isolation and characterization of products from a subtractive cDNA library from the haemolymph of Penaeus monodon experimentally infected with white spot syndrome virus (WSSV). One cDNA derived from up-regulated mRNA was identified. A homology search indicated similarity to the putative protein syntenin (TE8). The nearly complete nucleotide sequence of TE8 was obtained by rapid amplification of cDNA (RACE). Its putative protein product contained a tandem repeat of PDZ domains (postsynaptic density protein or PSD-95, D1gA and ZO-1). We propose that TE8 may function as an adapter that couples PDZ-binding protein(s) in a signaling pathway involved in the shrimp response to WSSV.

引用

页码：19 / 25

页数：7

共 43 条

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