Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study

被引:511
作者
Mahabadi, Amir A. [1 ]
Massaro, Joseph M. [2 ,5 ]
Rosito, Guido A. [1 ,6 ]
Levy, Daniel [5 ]
Murabito, Joanne M. [3 ,4 ,5 ]
Wolf, Philip A. [3 ,4 ,5 ]
O'Donnell, Christopher J. [5 ,7 ]
Fox, Caroline S. [5 ,8 ]
Hoffmann, Udo [1 ]
机构
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Radiol,Cardiac MR PET CT Program, Boston, MA 02114 USA
[2] Boston Univ, Dept Math, Boston, MA 02215 USA
[3] Boston Univ, Dept Med, Boston, MA 02215 USA
[4] Boston Univ, Dept Neurol, Boston, MA 02215 USA
[5] NHLBI, Framingham Heart Study, Framingham, MA USA
[6] Fed Fdn Sch Med Sci Porto Alegre, Porto Alegre, RS, Brazil
[7] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA 02114 USA
[8] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
关键词
Pericardial fat; Visceral abdominal fat; Cardiovascular disease; Framingham Heart Study; Epidemiology; EPICARDIAL ADIPOSE-TISSUE; CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; METABOLIC SYNDROME; RISK-FACTORS; INSULIN-RESISTANCE; PLASMA-PROTEIN; OBESITY; ADIPONECTIN; CELL;
D O I
10.1093/eurheartj/ehn573
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of this study was to assess whether pericardial fat, intrathoracic fat, and visceral abdominal adipose tissue (VAT) are associated with the prevalence of cardiovascular disease (CVD). Participants from the Framingham Heart Study Offspring cohort underwent abdominal and chest multidetector computed tomography to quantify volumes of pericardial fat, intrathoracic fat, and VAT. Relations between each fat depot and CVD were assessed using logistic regression. The analysis of 1267 participants (mean age 60 years, 53.8% women, 9.7% with prevalent CVD) demonstrated that pericardial fat [odds ratio (OR) 1.32, 95% confidence interval (CI) 1.11-1.57; P = 0.002] and VAT (OR 1.35, 95% CI 1.11-1.57; P = 0.003), but not intrathoracic fat (OR 1.14, 95% CI 0.93-1.39; P = 0.22), were significantly associated with prevalent CVD in age-sex-adjusted models and after adjustment for body mass index and waist circumference. After multivariable adjustment, associations were attenuated (P > 0.14). Only pericardial fat was associated with prevalent myocardial infarction after adjusting for conventional measures of adiposity (OR 1.37, 95% CI 1.03-1.82; P = 0.03). Pericardial fat and VAT, but not intrathoracic fat, are associated with CVD independent of traditional measures of obesity but not after further adjustment for traditional risk factor. Taken together with our prior work, these findings may support the hypothesis that pericardial fat contributes to coronary atherosclerosis.
引用
收藏
页码:850 / 856
页数:7
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