Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa

被引：33

作者：

Ricca, V

Nacmias, B

Boldrini, M

Cellini, E

di Bernardo, M

Ravaldi, C

Tedde, A

Bagnoli, S

Placidi, GF

Rotella, CM

Sorbi, S

机构：

[1] Univ Florence, Dept Neurol & Psychiat Sci, Psychiat Unit, I-50134 Florence, Italy

[2] Univ Florence, Dept Neurol & Psychiat Sci, Neurol Unit, I-50134 Florence, Italy

[3] Univ Florence, Dept Clin Pathophysiol, Sect Metab Dis & Diabet, Florence, Italy

来源：

NEUROSCIENCE LETTERS | 2004年 / 365卷 / 02期

关键词：

Anorexia Nervosa; Bulimia Nervosa; genetics; eating disorder examination; psychopathology; quantitative traits;

D O I：

10.1016/j.neulet.2004.04.057

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Various studies have evaluated the possible role of the -1438 G/A polymorphism within the 5-HT2A receptor gene in the susceptibility to Eating Disorders (EDs). One hundred and forty-eight ED patients (EDp) and 89 control subjects were interviewed by means of the Eating Disorder Examination (EDE) and analyzed for distribution of the -1438 G/A polymorphism. Patients with the AA genotype suffering from Anorexia Nervosa and Bulimia Nervosa showed higher Weight and Shape Concern (P = 0.003 and P = 0.010, respectively) scores and greater overall severity of the ED psychopathology (EDE total score) (P = 0.012). The obtained preliminary data suggest the use of dimensional psychopathological measures in ED genetic studies. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：92 / 96

页数：5

共 20 条

[1] Association between 5-HT2A gene promoter polymorphism and anorexia nervosa [J].

Collier, DA ;

Arranz, MJ ;

Li, T ;

Mupita, D ;

Brown, N ;

Treasure, J .

LANCET, 1997, 350 (9075) :412-412

[2]

COLLIER DA, 2002, EATING DISORDERS OBE, P342

[3] Linkage analysis of anorexia nervosa incorporating behavioral covariates [J].

Devlin, B ;

Bacanu, SA ;

Klump, KL ;

Bulik, CM ;

Fichter, MM ;

Halmi, KA ;

Kaplan, AS ;

Strober, M ;

Treasure, J ;

Woodside, DB ;

Berrettini, WH ;

Kaye, WH .

HUMAN MOLECULAR GENETICS, 2002, 11 (06) :689-696

[4] Biometrical genetics [J].

Evans, DM ;

Gillespie, NA ;

Martin, NG .

BIOLOGICAL PSYCHOLOGY, 2002, 61 (1-2) :33-51

[5]

Fairburn Christopher G., 1993, P317

[6]

First M., 1995, STRUCTURED CLIN INTE

[7]

GARNER DM, 2000, EATING DISORDERS OBE, P141

[8] The human genetics of anorexia nervosa [J].

Gorwood, P ;

Kipman, A ;

Foulon, C .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 480 (1-3) :163-170

[9] Evidence for a susceptibility gene for anorexia nervosa on chromosome 1 [J].

Grice, DE ;

Halmi, KA ;

Fichter, MM ;

Strober, M ;

Woodside, DB ;

Treasure, JT ;

Kaplan, AS ;

Magistretti, PJ ;

Goldman, D ;

Bulik, CM ;

Kaye, WH ;

Berrettini, WH .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (03) :787-792

[10] Candidate gene polymorphisms in eating disorders [J].

Hinney, A ;

Remschmidt, H ;

Hebebrand, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 410 (2-3) :147-159

← 1 2 →