Review. Hyaluronan: A powerful tissue engineering tool

被引：292

作者：

Allison, David D. ^{[1
]}

Grande-Allen, K. Jane ^{[1
]}

机构：

[1] Rice Univ, Dept Bioengn, Houston, TX 77251 USA

来源：

TISSUE ENGINEERING | 2006年 / 12卷 / 08期

关键词：

D O I：

10.1089/ten.2006.12.2131

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Hyaluronan (HA) is a versatile molecular tool with considerable potential for tissue engineering applications. The inclusion of HA has created biocompatible biomaterials and engineered tissues that can be crosslinked or degraded controllably and can facilitate angiogenesis, osteointegration, and cell phenotype preservation. The utility of HA in tissue engineering has been broadened further by the recently identified HA synthases, which can be manipulated to stimulate the endogenous production of HA by cells seeded within biomaterial scaffolds. Overall, HA shows great promise in the development of engineered tissues and biomaterials for a variety of biomedical needs including orthopedic, cardiovascular, pharmacologic, and oncologic applications.

引用

页码：2131 / 2140

页数：10

共 103 条

[1]

Aigner J, 1998, J BIOMED MATER RES, V42, P172, DOI 10.1002/(SICI)1097-4636(199811)42:2<172::AID-JBM2>3.0.CO

[2]

2-M

[3]

AMARNATH LP, 2005, BIOMATERIALS

[4] Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks [J].