Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide

被引：154

作者：

Enting, RH

Demopoulos, A

DeAngelis, LM

Abrey, LE

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY 10021 USA

[2] Univ Groningen Hosp, Dept Neurol, Groningen, Netherlands

来源：

NEUROLOGY | 2004年 / 63卷 / 05期

关键词：

D O I：

10.1212/01.WNL.0000137050.43114.42

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors evaluated the efficacy of a combination of rituximab and temozolomide for recurrent or refractory primary CNS lymphoma (PCNSL). Fifteen patients with a median age of 69 years had a 53% objective response rate with acceptable toxicity. Median overall survival is 14 months and median progression free survival of responding patients is 7.7 months. This combination merits further study and provides a reasonable therapeutic alternative for older patients with progressive PCNSL.

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页码：901 / 903

页数：3

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