Fungal LysM effectors: extinguishers of host immunity?

被引：184

作者：

de Jonge, Ronnie ^{[1
]}

Thomma, Bart P. H. J. ^{[1
]}

机构：

[1] Univ Wageningen & Res Ctr, Phytopathol Lab, NL-6709 PD Wageningen, Netherlands

来源：

TRENDS IN MICROBIOLOGY | 2009年 / 17卷 / 04期

关键词：

PATHOGEN CLADOSPORIUM-FULVUM; CAROTOVORA SUBSP CAROTOVORA; RECEPTOR-LIKE KINASES; HIDDEN MARKOV-MODELS; CYANOVIRIN-N; NEP1-LIKE PROTEINS; FUSARIUM-OXYSPORUM; VIRULENCE PROTEIN; CHITIN FRAGMENTS; PLANT-CELLS;

D O I：

10.1016/j.tim.2009.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysin motifs (LysMs) have been recognized in prokaryotes and plants as carbohydrate-binding protein modules. Recently, a novel virulence factor with LysMs was characterized from the plant pathogenic fungus Cladosporium fulvum. Here, we present a survey of public sequence data of 70 fungal species to demonstrate that putatively secreted LysM-containing proteins are widespread in the fungal kingdom, as they are found in mammalian and plant pathogenic species, in addition to saprophytes. We propose that these putative LysM effectors might have a role in sequestration of chitin oligosaccharides - breakdown products of fungal cell walls that are released during invasion and act as triggers of host immunity - to dampen host defence.

引用

页码：151 / 157

页数：7

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