SIV-Induced Instability of the Chimpanzee Gut Microbiome

被引：71

作者：

Moeller, Andrew H. ^{[1
]}

Shilts, Meghan ^{[1
]}

Li, Yingying ^{[2
]}

Rudicell, Rebecca S. ^{[3
]}

Lonsdorf, Elizabeth V. ^{[4
]}

Pusey, Anne E. ^{[5
]}

Wilson, Michael L. ^{[6
]}

Hahn, Beatrice H. ^{[2
]}

Ochman, Howard ^{[1
]}

机构：

[1] Yale Univ, Dept Ecol & Evolut Biol, New Haven, CT 06511 USA

[2] Univ Penn, Perelman Sch Med, Dept Med & Microbiol, Philadelphia, PA 19104 USA

[3] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA

[4] Franklin & Marshall Coll, Dept Phys, Lancaster, PA 17604 USA

[5] Duke Univ, Dept Evolut Anthropol, Durham, NC 27705 USA

[6] Univ Minnesota, Dept Anthropol, Minneapolis, MN 55455 USA

来源：

CELL HOST & MICROBE | 2013年 / 14卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY VIRUS-INFECTION; HIV-INFECTION; SCHWEINFURTHII; ENTEROTYPES; AIDS;

D O I：

10.1016/j.chom.2013.08.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Simian immunodeficiency virus of chimpanzees (SIVcpz) is the ancestor of human immunodeficiency virus type 1 (HIV-1), the etiologic agent of acquired immunodeficiency syndrome (AIDS) in humans. Like HIV-1-infected humans, SIVcpz-infected chimpanzees can develop AIDS-like symptoms. Because SIVcpz/HIV-1 may disrupt regulation of the gut microbiome and because it has not been possible to sample individual humans pre- and postinfection, we investigated the influence of infection on gut communities through long-term monitoring of chimpanzees from Gombe National Park, Tanzania. SIVcpz infection accelerated the rate of change in gut microbiota composition within individuals for periods of years after the initial infection and led to gut communities marked by high frequencies of pathogen-containing bacterial genera absent from SIVcpz-negative individuals. Our results indicate that immune function maintains temporally stable gut communities that are lost when individuals become infected with SIVcpz.

引用

页码：340 / 345

页数：6

共 31 条

[1] Staphylococcus aureus:: A well-armed pathogen [J].

Archer, GL .

CLINICAL INFECTIOUS DISEASES, 1998, 26 (05) :1179-1181

[2] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[3] QIIME allows analysis of high-throughput community sequencing data [J].

Caporaso, J. Gregory ;

Kuczynski, Justin ;

Stombaugh, Jesse ;

Bittinger, Kyle ;

Bushman, Frederic D. ;

Costello, Elizabeth K. ;

Fierer, Noah ;

Pena, Antonio Gonzalez ;

Goodrich, Julia K. ;

Gordon, Jeffrey I. ;

Huttley, Gavin A. ;

Kelley, Scott T. ;

Knights, Dan ;

Koenig, Jeremy E. ;

Ley, Ruth E. ;

Lozupone, Catherine A. ;

McDonald, Daniel ;

Muegge, Brian D. ;

Pirrung, Meg ;

Reeder, Jens ;

Sevinsky, Joel R. ;

Tumbaugh, Peter J. ;

Walters, William A. ;

Widmann, Jeremy ;

Yatsunenko, Tanya ;

Zaneveld, Jesse ;

Knight, Rob .

NATURE METHODS, 2010, 7 (05) :335-336

[4] Natural SIV Hosts: Showing AIDS the Door [J].

Chahroudi, Ann ;

Bosinger, Steven E. ;

Vanderford, Thomas H. ;

Paiardini, Mirko ;

Silvestri, Guido .

SCIENCE, 2012, 335 (6073) :1188-1193

[5] Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB [J].

DeSantis, T. Z. ;

Hugenholtz, P. ;

Larsen, N. ;

Rojas, M. ;

Brodie, E. L. ;

Keller, K. ;

Huber, T. ;

Dalevi, D. ;

Hu, P. ;

Andersen, G. L. .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (07) :5069-5072

[6] Search and clustering orders of magnitude faster than BLAST [J].

Edgar, Robert C. .

BIOINFORMATICS, 2010, 26 (19) :2460-2461

[7] Molecular Characterization of Stool Microbiota in HIV-Infected Subjects by Panbacterial and Order-Level 16S Ribosomal DNA (rDNA) Quantification and Correlations With Immune Activation [J].

Ellis, Collin L. ;

Ma, Zhong-Min ;

Mann, Surinder K. ;

Li, Chin-Shang ;

Wu, Jian ;

Knight, Thomas H. ;

Yotter, Tammy ;

Hayes, Timothy L. ;

Maniar, Archana H. ;

Troia-Cancio, Paolo V. ;

Overman, Heather A. ;

Torok, Natalie J. ;

Albanese, Anthony ;

Rutledge, John C. ;

Miller, Christopher J. ;

Pollard, Richard B. ;

Asmuth, David M. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2011, 57 (05) :363-370

[8] Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis [J].

Gori, Andrea ;

Tincati, Camilla ;

Rizzardini, Giuliano ;

Torti, Carlo ;

Quirino, Tiziana ;

Haarman, Monique ;

Ben Amor, Kaouther ;

van Schaik, Jacqueline ;

Vriesema, Aldwin ;

Knol, Jan ;

Marchetti, Giulia ;

Welling, Gjalt ;

Clerici, Mario .

JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (02) :757-758

[9] Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons [J].

Haas, Brian J. ;

Gevers, Dirk ;

Earl, Ashlee M. ;

Feldgarden, Mike ;

Ward, Doyle V. ;

Giannoukos, Georgia ;

Ciulla, Dawn ;

Tabbaa, Diana ;

Highlander, Sarah K. ;

Sodergren, Erica ;

Methe, Barbara ;

DeSantis, Todd Z. ;

Petrosino, Joseph F. ;

Knight, Rob ;

Birren, Bruce W. .

GENOME RESEARCH, 2011, 21 (03) :494-504

[10] Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome [J].

Handley, Scott A. ;

Thackray, Larissa B. ;

Zhao, Guoyan ;

Presti, Rachel ;

Miller, Andrew D. ;

Droit, Lindsay ;

Abbink, Peter ;

Maxfield, Lori F. ;

Kambal, Amal ;

Duan, Erning ;

Stanley, Kelly ;

Kramer, Joshua ;

Macri, Sheila C. ;

Permar, Sallie R. ;

Schmitz, Joern E. ;

Mansfield, Keith ;

Brenchley, Jason M. ;

Veazey, Ronald S. ;

Stappenbeck, Thaddeus S. ;

Wang, David ;

Barouch, Dan H. ;

Virgin, Herbert W. .

CELL, 2012, 151 (02) :253-266

← 1 2 3 4 →