Interleukin receptor-associated kinase (IRAK-4) deficiency associated with bacterial infections and failure to sustain antibody responses

被引：66

作者：

Day, N

Tangsinmankong, N

Ochs, H

Rucker, R

Picard, C

Casanova, JL

Haraguchi, S

Good, R

机构：

[1] Univ S Florida, Div Allergy & Immunol, Dept Pediat, St Petersburg, FL 33620 USA

[2] All Childrens Hosp, St Petersburg, FL USA

[3] Univ Washington, Sch Med, Div Immunol Infect Dis & Rheumatol, Dept Pediat, Seattle, WA USA

[4] Univ Paris 05, INSERM, U550, Fac Necker,Lab Genet Humaine Malad Infect, Paris, France

来源：

JOURNAL OF PEDIATRICS | 2004年 / 144卷 / 04期

关键词：

D O I：

10.1016/j.jpeds.2003.11.025

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We previously described a girl with recurrent episodes of pneumococcal pneumonia with septicemia and other infections,(1) ;found to have interleukin-1 receptor-associated kinase 4 deficiency (IRAK-4) deficieney.(2) In this report, we show that our patient is unable to sustain antibody responses either to polysaccharide or protein antigens or to a neoantigen-bacteriophage.

引用

页码：524 / 526

页数：3

共 7 条

[1] Pneumococcal type 22F polysaccharide absorption improves the specificity of a pneumococcal-polysaccharide enzyme-linked immunosorbent assay
Concepcion, NF
Frasch, CE
[J]. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2001, 8 (02) : 266 - 272
[2] DOYLE A, 1997, CELL TISSUE CULTURE
[3] Interleukin 12 deficiency associated with recurrent infections
Haraguchi, S
Day, NK
Nelson, RP
Emmanuel, P
Duplantier, JE
Christodoulou, CS
Good, RA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) : 13125 - 13129
[4] Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections
Medvedev, AE
Lentschat, A
Kuhns, DB
Blanco, JCG
Salkowski, C
Zhang, SL
Arditi, MH
Gallin, JI
Vogel, SN
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (04) : 521 - 531
[5] IMMUNOLOGIC RESPONSES TO BACTERIOPHAGE PHI-X-174 IN IMMUNODEFICIENCY DISEASES
OCHS, HD
DAVIS, SD
WEDGWOOD, RJ
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1971, 50 (12) : 2559 - &
[6] Pyogenic bacterial infections in humans with IRAK-4 deficiency
Picard, C
Puel, A
Bonnet, M
Ku, CL
Bustamante, J
Yang, K
Soudais, C
Dupuis, S
Feinberg, J
Fieschi, C
Elbim, C
Hitchcock, R
Lammas, D
Davies, G
Al-Ghonaium, A
Al-Rayes, H
Al-Jumaah, S
Al-Hajjar, S
Al-Mohsen, IZ
Frayha, HH
Rucker, R
Hawn, TR
Aderem, A
Tufenkeji, H
Haraguchi, S
Day, NK
Good, RA
Gougerot-Pocidalo, MA
Ozinsky, A
Casanova, JL
[J]. SCIENCE, 2003, 299 (5615) : 2076 - 2079
[7] Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
Suzuki, N
Suzuki, S
Duncan, GS
Millar, DG
Wada, T
Mirtsos, C
Takada, H
Wakeham, A
Itie, A
Li, SY
Penninger, JM
Wesche, H
Ohashi, PS
Mak, TW
Yeh, WC
[J]. NATURE, 2002, 416 (6882) : 750 - 754

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