Transcriptional squelching re-examined

被引：44

作者：

Natesan, S

Rivera, VM

Molinari, E

Gilman, M

机构：

[1] ARIAD Gene Therapeutics,

[2] Inc.,undefined

来源：

NATURE | 1997年 / 390卷 / 6658期

关键词：

D O I：

10.1038/37019

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The introduction of a potent transcriptional activator into eukaryotic cells can paradoxically suppress the transcription of a co-introduced target gene1,2,3. This so-called ‘squelching’ is thought to result from titration of one or more general transcription factors (GTFs)4, indicating that GTFs might be in limited supply within the cell5,6. We now find that in mammalian cells, squelching is limited to episomal target genes, whereas genes integrated into cellular chromatin are immune.

引用

页码：349 / 350

页数：2

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