Three-component one-pot synthesis of functionalised (Z)-4-benzylidene (and alkenylidene) pyrrolidines

被引：26

作者：

Azoulay, S ^{[1
]}

Monteiro, N ^{[1
]}

Balme, G ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, Lab Chim Organ 1, UMR 5622, F-69622 Villeurbanne, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 51期

关键词：

multicomponent reactions; palladium catalysis; carbocyclisation; pyrrolidines;

D O I：

10.1016/S0040-4039(02)02383-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-component synthesis of stereodefined 4-benzylidene-(or alkenylidene)-pyrrolidines from simple, readily available starting materials is described. This one-pot process is initiated by a conjugate addition of a propargylamine to a gem-diactivated olefin subsequently followed by a carbopalladation involving an aryl halide (or vinyl triflate). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：9311 / 9314

页数：4

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