Alzheimer's disease is a synaptic failure

被引：3470

作者：

Selkoe, DJ

机构：

[1] Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

[2] Harvard Univ, Ctr Neurodegenerat & Repair, Boston, MA 02115 USA

来源：

SCIENCE | 2002年 / 298卷 / 5594期

关键词：

D O I：

10.1126/science.1074069

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid beta protein.

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页码：789 / 791

页数：4

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