9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic produced by Micromonospora sp. SA246

被引：10

作者：

Yeo, WH

Yun, BS

Back, NI

Kim, YH

Kim, SS

Park, EK

Whang, KS

Yu, SH

机构：

[1] CHUNGNAM NATL UNIV,DEPT AGR BIOL,TAEJON 305764,SOUTH KOREA

[2] KOREA GINSENG & TOBACCO RES INST,TAEJON 305345,SOUTH KOREA

[3] KIST,KOREA RES INST BIOSCI & BIOTECHNOL,TAEJON,SOUTH KOREA

[4] KYUNG HEE UNIV,COLL IND,KYONGGI DO 449701,SOUTH KOREA

[5] MOKWON UNIV,DEPT MICROBIOL,TAEJON 301729,SOUTH KOREA

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 07期

关键词：

D O I：

10.7164/antibiotics.50.546

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic, was isolated from a soil microorganism SA246 which was identified as Micromonospora sp. The molecular formula of 9-hydroxycrisamicin A was determined as C32H22O13 based on the HRFAB-MS analysis, and the structure was determined by various NMR experiments. 9-Hydroxycrisamicin A showed weak antimicrobial activity against Gram-positive bacteria and strong cytotoxic activity against some human cancer cell lines such as SK-OV-3 (ovarian), HCT15 (colon), SK-MEL-2. (melanoma), A549(lung), XF498 (central nervous system) with ED50 of 0.47 similar to 0.65 mu g/ml.

引用

页码：546 / 550

页数：5

共 10 条

[1] CLASSIFICATION OF STREPTOMYCES SPORE SURFACES INTO 5 GROUPS [J].