Enantioselective Palladium-Catalyzed Direct Arylations at Ambient Temperature: Access to Indanes with Quaternary Stereocenters

被引：153

作者：

Albicker, Martin R. ^{[1
]}

Cramer, Nicolai ^{[1
]}

机构：

[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 48期

关键词：

asymmetric catalysis; C-H activation; direct arylation; palladium; stereocenters; H BOND FUNCTIONALIZATION; PROTON-ABSTRACTION MECHANISM; C-H; ACTIVATION; ACID; EFFICIENT;

D O I：

10.1002/anie.200905060

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tadaa: The title reaction proceeds under essentially neutral reaction conditions at ambient temperature with a taddol-based phosphoramidite ligand L allowing the creation of indanes with quaternary stereogenic centers in high enantiomeric excess (see scheme; Tf=trifluoromethanesulfonyl, DMAc = dimethylacetamide). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9139 / 9142

页数：4

共 60 条

[1]

Ackermann L, 2007, TOP ORGANOMETAL CHEM, V24, P35, DOI 10.1007/3418_2007_062

[2] Aryl-aryl bond formation by transition-metal-catalyzed direct arylation [J].