Polyelectrolyte complexes: A review of their applicability in drug delivery technology

被引：254

作者：

Lankalapalli, S. ^{[1
]}

Kolapalli, V. R. M. ^{[2
]}

机构：

[1] Raghu Coll Pharm, Visakhapatnam 531162, Andhra Pradesh, India

[2] Andhra Univ, Univ Coll Pharmaceut Sci, Visakhapatnam 530003, Andhra Pradesh, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2009年 / 71卷 / 05期

关键词：

Polyelectrolyte complex; polymer; drug delivery; polyion; electrostatic interaction; CONTROLLED-RELEASE; INTERPOLYMER COMPLEXATION; CHITOSAN-ALGINATE; NUCLEIC-ACIDS; BEHAVIOR; PRECIPITATION; FILMS; FORMULATION; PROTEINS; POLYMER;

D O I：

10.4103/0250-474X.58165

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Over the past several years, great advances have been made towards novel drug delivery systems. The phenomena of interpolymer interactions and formation of polyelectrolyte complexes have been the focus of intensive fundamental and applied research. Interpolyelectrolyte complexes combine unique physicochemical properties with high biocompatibility. Studies have been carried out on many different polymer blends and types. Such combinations may possess unique properties that are different from those of individual component. The present review emphasizes on the applicability of polyelectrolyte complexes in drug delivery technology.

引用

页码：481 / 487

页数：7

共 73 条

[1]

ALBANO AA, 2002, Patent No. 6350786

[2]

ALEXANDER K, 2004, J CHEM PHYS, V20, P404

[3]

FORMULATION AND IN-VITRO IN-VIVO EVALUATION OF BUCCOADHESIVE MORPHINE-SULFATE TABLETS [J].

ANLAR, S ;

CAPAN, Y ;

GUVEN, O ;

GOGUS, A ;

DALKARA, T ;

HINCAL, AA .

PHARMACEUTICAL RESEARCH, 1994, 11 (02) :231-236

[4]

Conductimetric study of the interpolyelectrolyte reaction between chitosan and polygalacturonic acid [J].

Argüelles-Monal, W ;

Cabrera, G ;

Peniche, C ;

Rinaudo, M .

POLYMER, 2000, 41 (07) :2373-2378

[5]

PRECIPITATION OF NUCLEIC-ACIDS WITH POLYETHYLENEIMINE AND CHROMATOGRAPHY OF NUCLEIC-ACIDS AND PROTEINS ON IMMOBILIZED POLYETHYLENEIMINE [J].

ATKINSON, A ;

JACK, GW .

BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 308 (01) :41-52

[6]

Controlled release of estradiol solubilized in carbopol/surfactant aggregates [J].

Barreiro-Iglesias, R ;

Alvarez-Lorenzo, C ;

Concheiro, A .

JOURNAL OF CONTROLLED RELEASE, 2003, 93 (03) :319-330

[7]

Carrageenan-oligochitosan microcapsules: optimization of the formation process [J].

Bartkowiak, A ;

Hunkeler, D .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2001, 21 (04) :285-298

[8]

PRACTICAL ANALYSIS OF COMPLEX COACERVATE SYSTEMS [J].

BURGESS, DJ .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1990, 140 (01) :227-238

[9]

Polysaccharide hydrogels for protein drug delivery [J].

Chen, J ;

Jo, S ;

Park, K .

CARBOHYDRATE POLYMERS, 1995, 28 (01) :69-76

[10]

CHERNGJU K, 1995, EUR POLYM J, V31, P937

← 1 2 3 4 5 6 7 8 →