Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans

被引：541

作者：

Rodrigues, Sarina M. ^{[1
,3
]}

Saslow, Laura R. ^{[2
]}

Garcia, Natalia ^{[2
]}

John, Oliver P. ^{[1
,2
]}

Keltner, Dacher ^{[2
]}

机构：

[1] Univ Calif Berkeley, Inst Personal & Social Res, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA

[3] Oregon State Univ, Dept Psychol, Corvallis, OR 97331 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 50期

关键词：

emotional; polymorphism; social; HIGH-FUNCTIONING AUTISM; ASPERGER-SYNDROME; SOCIAL-BEHAVIOR; BRAIN OXYTOCIN; RESPONSES; SUPPORT; OXTR; FEAR; MIND; ASSOCIATION;

D O I：

10.1073/pnas.0909579106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Oxytocin, a peptide that functions as both a hormone and neurotransmitter, has broad influences on social and emotional processing throughout the body and the brain. In this study, we tested how a polymorphism (rs53576) of the oxytocin receptor relates to two key social processes related to oxytocin: empathy and stress reactivity. Compared with individuals homozygous for the G allele of rs53576 (GG), individuals with one or two copies of the A allele (AG/AA) exhibited lower behavioral and dispositional empathy, as measured by the "Reading the Mind in the Eyes'' Test and an other-oriented empathy scale. Furthermore, AA/AG individuals displayed higher physiological and dispositional stress reactivity than GG individuals, as determined by heart rate response during a startle anticipation task and an affective reactivity scale. Our results provide evidence of how a naturally occurring genetic variation of the oxytocin receptor relates to both empathy and stress profiles.

引用

页码：21437 / 21441

页数：5

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